EFFECT OF FUCOIDAN, HABERLEA RHODOPENSIS AND PROPOLIS
ON MOBILIZATION OF THE CD34+ STEM CELLS IN RATS
ELISAVETA G. APOSTOLOVA1*, VESELA KOKOVA1, ZHIVKO PEYCHEV2, STELA PEYCHEVA3, APOSTOL APOSTOLOV4
1Department of Pharmacology and Drug Toxicology, Faculty of Pharmacy, Medical University, Plovdiv, Bulgaria
2Department of Medical Informatics, Biostatistics and Interactive Education, Faculty of Public Health, Medical University,
Plovdiv, Bulgaria
3Department of Paediatric Dentistry, Faculty of Dental Medicine, Medical University, Plovdiv, Bulgaria
4Department of Anaesthesiology and Intensive Care, “St. George” University Hospital, Plovdiv, Bulgaria
*corresponding author: apostolova1212@gmail.com
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Abstract:
We evaluated the influence of fucoidan, Haberlea rhodopensis (H. rhodopensis) and propolis on the hematopoietic stem cells
(CD34+) levels into the blood stream of rats. Four groups of male Wistar rats (n = 10) were treated intraperitoneally as
follows: 1st group – 0.9% NaCl; 2nd group – fucoidan (100 mg/kg b.w.); 3rd group – H. rhodopensis (50 mg/kg b.w.) and 4th
group – propolis (100 mg/kg b.w.). Two hours after a single administration of the substances, blood samples were collected
and analysed. We found a significant increase in the number of CD34+ cells in the blood stream after the administration of
the tested substances. Fucoidan also caused a significant increase in the number of leukocytes compared to the control group.
These results show that the tested substances could mobilize stem cells in the peripheral blood of rats. Fucoidan may increase
the count of circulating white blood cells (WBC), H. rhodopensis decreases this value, while propolis does not influence
leukocytes level in peripheral blood.

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