ISOBOLAR ANALYSIS OF THE BINARY FIXED-RATIO COMBINATION
OF ACETYLSALICILIC ACID-ACETAMINOPHEN
VERONICA BILD1,2,4, DANIELA CARMEN ABABEI1*, MONICA NEAMȚU1, ALEXANDRU VASINCU1, WALTHER BILD2,3, GABRIELA DUMITRIȚA STANCIU4, BOGDAN IONEL TAMBA4, GHEORGHE SOLCAN5, SORIN BEȘCHEA CHIRIAC5
1“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmacodynamics and Clinical Pharmacy
Department, Iași, Romania
2Center of Biomedical Research of the Romanian Academy, Iași, Romania
3“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Medicine, Physiology Department, Iași, Romania
4“Grigore T. Popa” University of Medicine and Pharmacy, CEMEX Department, Iași, Romania
5“Ion Ionescu de la Brad” University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine,
Iași, Romania
*corresponding author: dana.ababei@gmail.com
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Abstract:
The present study is part of a series of larger investigations concerning combinations of paracetamol with several other drug
substances, as a rational modality of pain therapy. By using a nociception model with chemical stimulus (Zymosan A) and
the administration of fixed-ratio dose sequences of paracetamol and acetylsalicylic acid we attempt the identification of the
type of pharmacodynamic interaction between those two substances. The evaluation of the nociceptive response is quantal,
while for the evaluation of the interaction we have used the isobolar analysis (composite additive line method). The data
obtained suggested a synergistic interaction, demonstrated by the following parameters: Zadd = 253.16 ± 33.90 mg/kg body
weight (b.w.), Zmix = 75.00 ± 19.02 mg/kg b.w, Zmix < Zadd, γ = 0.296 (Ft = 4.460, Fc = 14.414, Tt = 3.925, Tc = 4.275 p < 0.01).

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