CHITOSAN MICROPARTICLES LOADED WITH ANTIDIABETIC
DRUGS – PREPARATION AND CHARACTERIZATION
IUSTINA AVRAM1, FLORENTINA GIANINA LUPAŞCU1, LUMINIŢA CONFEDERAT1, SANDRA MĂDĂLINA CONSTANTIN1, CRISTINEL IONEL STAN2*, LENUŢA PROFIRE1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy,
16 Universităţii Street, 700115, Iaşi, România
2Department of Morphofunctional Science, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy,
16 Universităţii Street, 700115, Iaşi, România
*corresponding author: cristi_stan00@yahoo.com
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Abstract:
The objective of this study was to develop new binary polymeric systems based on chitosan in order to achieve an
improvement of the pharmacokinetic and pharmacological profile of the two most used oral antidiabetic drugs - metformin
and glibenclamide. The presence of the antidiabetic drugs in the polymer matrix was proved using IR spectroscopy. The
optimized formulations were studied in terms of morphology, particle size, swelling degree and loading efficiency. The
binary polymeric formulations (chitosan-metformin-glibenclamide) were characterized by the swelling degree and loading
efficiency, higher than the unitary polymeric systems (chitosan-metformin and chitosan-glibenclamide). The highest loading
efficiency was shown by the chitosan-metformin-glibenclamide formulation in 1:0.5:0.5 ratio (w/w/w).

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