EFFECTS OF PROPOFOL ON THE DIFFERENTIATION OF NORMAL
SPLEEN DENDRITIC CELLS TO IMMUNE CELLS AND ITS
MECHANISM OF ACTION
XUANYI PAN1, LILI YUAN2, MEILI YANG3, CAIHUA LIU4*
1Department of Anaesthesiology, Affiliated Hospital of Hebei University, Hebei, 071000, China
2Department of Anaesthesiology, Wuhan No. 5 Hospital, Hubei, 430050, China
3 Baoding Institute of Food and Drug Control, Hebei, 071000, China
4Department of Anaesthesiology, The Central Hospital of Wuhan, 430014, China
*corresponding author: panxuany@sohu.com
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Abstract:
Based on reports regarding the effect of propofol, in different concentrations on the differentiation of normal spleen dendritic
cells to immune cells, this study aimed to clarify the anti-inflammatory and immunomodulatory effect of propofol. Spleen
dendritic cells were selected as research material, isolated from male mice. Propofol in different concentrations was cultured
with the dendritic cells stimulated with lipopolysaccharide (LPS). The expression of spleen dentritic cells during
differentiation in different cell groups was detected and analysed by flow cytometry. Propofol in different concentrations and
LPS had low influence on the survival rate of spleen dendritic cells. It inhibited the expression of inflammatory cytokines and
significantly lowered the expression level of dendritic cells during differentiation in a dose-dependent manner.

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