BRUNO ŞTEFAN VELESCU1#, VALENTINA ANUŢA2#*, ANTON ALDEA3#, MARIANA JINGA4,7#, PAVEL CĂLIN COBELESCHI5#, CRISTINA ELENA ZBÂRCEA1#, VALENTINA UIVAROSI6#
1“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacology and Clinical
Pharmacy, 6 Traian Vuia Str., 020956, Bucharest, Romania
2“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Physical and Colloidal
Chemistry, 6 Traian Vuia Str., 020956, Bucharest, Romania
3 BLD Pharma SRL, 96A Intrarea Sulfinei, 077125, Măgurele, Jud Ilfov, Romania
4”Dr. Carol Davila” Central Military Emergency Hospital, Internal Medicine and Gastroenterology Clinic, 88 Mircea
Vulcănescu St., 10816, Bucharest, Romania
5Transilvania University, Faculty of Medicine, Department of Internal Medicine, 56th Nicolae Bălcescu St., Brașov, Romania
6“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Inorganic Chemistry, 6 Traian
Vuia Str., 020956, Bucharest, Romania
7“Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine, Eroilor Sanitari Blvd, Bucharest.
*corresponding author: vali_anuta@yahoo.com
# All authors have equal contribution
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Abstract:
Various vanadium compounds demonstrated decreasing blood sugar levels in different diabetes animal models, and are
considered to be promising antidiabetic agents. Oxovanadium(IV) complexes with flavonoid ligands, with beneficial effects
in diabetic pathology, like the complex di-μ-hydroxobis(quercetinatooxovanadium)(IV), proved to decrease the elevated
blood sugar levels and the total cholesterol, without impact on the insulin levels in alloxan induced diabetic rats. The aim of
the study was to evaluate the effect of quercetin and vanadyl sulphate on rats exposed to alloxan, as diabetogenic agent. The
rats’ treatment consisted in daily oral administered doses of 0.01 mmol/kg b.w. of vanadyl sulphate, 0.02 mmol/kg b.w. of
quercetin and respectively 0.01/0.02 mmol/kg b.w. of vanadyl sulphate - quercetin mixture, over a 4 weeks period. The
experimental results pointed out protective effects of quercetin and vanadyl sulphate in alloxan exposed rats on the induced
diabetic onset, rats’ glycaemia and impaired lipid metabolism.






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