IN VITRO ANTIMITOTIC, ANTIPROLIFERATIVE AND GC-MS STUDIES
ON THE METHANOLIC EXTRACT OF ENDOPHYTIC FUNGI,
PENICILLIUM SPECIES OF TABEBUIA ARGENTEA BUR & K. SCH
GOVINDAPPA MELAPPA1*, SHILPASHREE CB2, CHANNABASAVA2, BHARATHI PRAKASH3
1Department of Biotechnology, Dayananda Sagar College of Engineering, Shavige Malleswara Hills, Kumaraswamy Layout,
Bengaluru-560078, Karnataka, India
2Endophytic Natural Product Laboratory, Department of Biotechnology, Shridevi Institute of Engineering & Technology,
Sira Road, Tumkur-572 106, Karnataka, India
3Department of Microbiology, University College, Mangalore University, Hampankatta, Mangalore-575 001, D.K.,
Karnataka, India
*corresponding author: dravidateja07@gmail.com, endophytessiet@gmail.com
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Abstract:
The present research was aimed to identify the metabolites in the methanolic extract of endophytic fungi, Penicillium species
of Tabebuia argentea and evaluated the extract, in order to emphasize their in vitro cytotoxic activities. The Penicillium
species extract was evaluated for cytotoxicity and antiproliferative activity and we identified the phytochemicals present in
the extract by a GC-MS method. The actively growing onion root cells were inhibited by arresting the cells at various stages
of cell cycles. The growth of yeast was also inhibited by inducing necrosis. 18 different phytochemicals were identified in the
extract of Penicillium species by GC-MS and few of these compounds have significance in anticancer activity. Hence, the
endophyte, Penicillium species contains very potent phytochemicals depicting a strong cytotoxic activity. Further research is
needed to extract the active molecules and to verify their potential anticancer activity.

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