THE INFLUENCE OF BIDENS TRIPARTITA EXTRACTS ON PSYCHOMOTOR ABILITIES AND COGNITIVE FUNCTIONS IN RATS
CĂTĂLINA ELENA LUPUȘORU1, ELIZA GRAȚIELA POPA2, RAUL BOGDAN SANDU1, BEATRICE ROZALINA BUCA1, LILIANA MITITELU-TARȚĂU1*, RAOUL VASILE LUPUȘORU3
“Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115, Iași, Romania
1Faculty of Medicine, Department of Pharmacology-Algesiology
2Faculty of Pharmacy, Department of Pharmaceutical Technology
3Faculty of Medicine, Department of Patho-Physiology
*corresponding author: lylytartau@yahoo.com
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Abstract:
The aim of the present study was the investigation of the effects of two Bidens tripartita (B. tripartita) extracts on the spatial
working memory in rat. The experiments were carried out on white Wistar rats (4 groups of 6 animals each), treated
intraperitoneally, as follows: Group I (Control): saline solution 0.1 mL/10 g b.w.; Group II (BT-alcoholic): 200 mg/kg b.w.
B. tripartita alcoholic extract; Group III (BT-aqueous): 250 mg/kg b.w. B. tripartita aqueous extract; Group IV (Mg): 1
mmol/kg b.w. magnesium chloride. The effects on the psycho-motor abilities and cognitive functions were evaluated using
the T-maze test, in order to investigate the influence of these two vegetal extracts on the short-term memory of laboratory
animals. B. tripartita aqueous extract determined a significant increase of the spontaneous alternation percentage, but less
accentuated than magnesium in the T-maze test in rats. The administration of B. tripartita alcoholic extract was associated
with a significant augmentation of the spontaneous alternation rate, but less intense than those produced by the aqueous
extract in this behavioural model. The treatment with both B. tripartita aqueous and alcoholic extracts resulted in a
facilitation of spatial learning, an improvement of the short-term memory and a weak anxiolytic effect in rat.

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