CHROMIUM PICOLINAT INFLUENCE ON BRAIN REWARD
SYSTEM IN NAÏVE AND MORPHINE – TREATED RATS
MIHAI NECHIFOR1*, DIANA CIUBOTARIU1
1Pharmacology Department, “Gr. T. Popa” University of Medicine and Pharmacy, Iași, Romania
*corresponding author: mihainechif@yahoo.com
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Abstract:
In this study, it was assessed the influence of chromium picolinate (CrPi) on the reward system in rats. For this, we have used
the conditioned place preference technique (CPP). We have worked on 6 groups, each of 10 Wistar adult male rats. CrPi was
given intraperitoneal, in doses of 0.05 and 0.01 mg/kg b.w., 2 h before conditioning sessions. We have also assessed the CrPi
effect on morphine-induced CPP. Our results showed that CrPi significantly increased the time spent in the conditioning
chamber in a dose-dependent manner (by 19.18 ± 7.67%, p < 0.05 for CrPi 0.01 mg/kg b.w. and by 35.20 ± 12.40%, p < 0.01
for CrPi 0.05 mg/kg b.w. post-conditioning time vs. pre-conditioning time). In the case of association between morphine and
CrPi, both CrPi doses determined a slight but significant increase of morphine stimulating effect on the reward system (p < 0.05).

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