COMPARATIVE STUDY OF ANTIMICROBIALS USE AND
THE ANTIBIOTIC RESISTANCE OF GRAM NEGATIVE
STRAINS
MIRELA VOICU1, CARMEN CRISTESCU1*, CRISTINA ELENA ZBÂRCEA2, ADRIAN VOICU3, VALENTINA BUDA1, LIANA SUCIU1, MARIA SUCIU1, MARIA PROKS1, VERONICA BILD4
1“Victor Babeș” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacology-Clinical
Pharmacy, Timişoara, Romania
2“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacology-Clinical
Pharmacy, Bucharest, Romania
3“Victor Babeș” University of Medicine and Pharmacy, Faculty of Medicine, Department of Functional Sciences, Timişoara,
Romania
4 “Gr. T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacology-Clinical
Pharmacy, Iaşi, Romania
*corresponding author: carmencristescu@umft.ro
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Abstract:
The aim of this study was to perform a comparative evaluation of antibiotics use in the Surgery Department of Timișoara
Regional Hospital, Romania, in the first three consecutive months of the year 2015, comparatively with the same interval of
the year 2016. For every patient was set up a personal record containing information about: age, diagnosis, pathological
product collected, the identified germ, antibiogram, pharmaceutical form of administered antibiotic, dose, number of
administrations/day, duration of therapy. Antibiotics specific intake was calculated according to the Defined Daily Dose
(DDD)/1000 patients/day. It was revealed, for the monitored antibiotics classes, an increase in the use of fluoroquinolones,
accompanied by a decrease of the prescriptions for the other classes. This study also revealed a decrease in the use of
cephalosporins, aminoglycosides and carbapenems in the first trimester of 2016, compared with the similar interval of the
year 2015 and a significant increase of the resistance of E. coli and Klebsiella spp. for gentamicin in 2016 compared with 2015.

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