GELUCIRE BASED FLOATING EMULSION GEL BEADS:
A POTENTIAL CARRIER FOR SUSTAINED STOMACH SPECIFIC
DRUG DELIVERY
SHASHANK SONI1, NAVNEET VERMA1, ANURAG VERMA1*, JAYANTA K. PANDIT2
1Department of Pharmaceutics, College of Pharmacy, IFTM, Moradabad, 244001, India
2Department of Pharmaceutics, Banaras Hindu University, Varanasi, India
*corresponding author: anuragverma_iftm@yahoo.co.in
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Abstract:
The purpose of the present study was to investigate the feasibility of Gelucire based floating emulsion gel beads as a
sustained stomach specific drug delivery carrier. Emulsion gel beads were prepared by extruding Gelucire (39/01 + 50/13) -
sodium alginate emulsions loaded with model drugs (metronidazole or norfloxacin) and buoyancy imparting agent (CaCO3)
into warm acidic CaCl2 solution (3% w/v, 37ºC). The beads formed were separated, washed with distilled water and dried for
12 h. The influences of Gelucire ratio (39/01:50/13) and total Gelucire concentration in the emulsion on bead buoyancy and
drug release were investigated. All the drug loaded beads were found to float on 0.1 M HCl (pH 1.2). The drug release in 0.1 M
HCl was found to be affected by total Gelucire content and its ratio (39/01:50/13). At Gelucire ratio 3:1 & 6:1 (total Gelucire
content 66 mg and 35 mg), drug release was extended up to 18 hours, whereas, at 4:1 ratio (25 mg) significantly rapid drug
release was observed.






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