PREVENTING CARDIAC COMPLICATIONS AFTER NON-CARDIAC
NON-VASCULAR SURGERY BY USING PERIOPERATIVE STATIN
THERAPY – A PROSPECTIVE STUDY IN CONSTANTA COUNTY,
ROMANIA
IRINEL-RALUCA PAREPA1#*, ANDRA-IULIA SUCEVEANU1#, LAURA MAZILU1#, AQEL MOHAMED2#, DANIEL NIŢĂ2#, LILIANA-ANA TUŢĂ1#
1"Ovidius" University, Faculty of Medicine, Constanţa, Romania
2“Vasile Cândea” Army Centre for Cardiovascular Diseases, Bucharest, Romania
*corresponding author: irinel_parepa@yahoo.com
#All authors had equal scientific contribution.
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Abstract:
The aim of the study was to evaluate if statins reduce the risk of cardiac events when given during perioperative period in patients
who undergo non-cardiac, non-vascular surgery. 1,380 “statin-naive” patients with no evidence of cardiac disease were
randomised for: rosuvastatin 10 mg/day (n = 691), and placebo (n = 689), given 10 days before and 20 days after surgery and
were followed-up 3 months after surgery. Endpoint was defined as new-onset angina, silent cardiac ischemia, non-fatal acute
coronary syndrome or fatal coronary heart disease. 82 patients (5.95%) suffered cardiac events during follow-up: 31 from
statin arm and 51 from placebo arm (p = 0.0029). After adjusting for variables, the statin arm had a relative-risk reduction of
39% (p = 0.0189) for cardiac events. No significant decrease in LDL-cholesterol was found in statin patients (p = 0.5664).
Perioperative statin therapy was protective against cardiac complications of non-cardiac non-vascular surgery, irrespective of
its lipid-lowering effect.

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