STUDIES ON THE ANTIMYCOBACTERIAL ACTION OF A NOVEL
COMPOUND OF THE THIADIAZOLE CLASS, 2-(PROPYL-THIO)-5H-
[1,3,4]-THIADIAZOLE[2,3-B]-QUINAZOLINE-5-ONE
SERGHEI POGREBNOI1#, CORNEL CHIRIŢĂ2#*, VLADIMIR VALICA5#, FLIUR MACAEV1#, MARIANA CARMEN CHIFIRIUC3,4#, CRINA KAMERZAN4#, LIVIA UNCU5#, ANDREI UNCU6#, SIMONA NEGREŞ2#, FLORIANA ELVIRA IONICĂ7#, FLORICA NICOLESCU8#, ILINCAMIHAELA MARANDIUC9#, EMIL ŞTEFĂNESCU2#
1Chemistry Institute of the Academy of Sciences of Moldova, 3 Academy Street, MD 2028, Chişinău, Moldova
2“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmacology and Clinical Pharmacy
Department, 6 Traian Vuia Street, 020956, Bucharest, Romania
3University of Bucharest, Faculty of Biology, Botany and Microbiology Department, 1-3 Portocalelor Street, 060101,
Bucharest, Romania
4Research Institute of the Bucharest University, 36-46 Mihail Kogălniceanu Boulevard., 050107, Bucharest, Romania
5“Nicolae Testemiţanu” State University for Medicine and Pharmacy, Scientific Medicines Centre, 66 Mălina Mică Street,
MD 2025, Chişinău, Moldova
6“Nicolae Testemiţanu” State University for Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Chemistry and
Toxicology Department, 66 Mălina Mică Street, MD 2025, Chişinău, Moldova
7Craiova University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Assistance and Communication with
the Patient Department, 2 Petru Rareş Street, 200349, Craiova, Romania
8“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Toxicology Department, 6 TraianVuia Street,
020956, Bucharest, Romania
9Bioplus Pharmacy, 2 Mihail Sebastian Street, 050784, Bucharest, Romania
*corresponding author: chirita.cornel@gmail.com
#All authors have equally contributed to the current paper.
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Abstract:
The aim of the current study was the antimicrobial screening of a newly synthesised thiadiazolic compound, 2-(propylthio)-
5H-[1,3,4]-thiadiazole[2,3-b]-quinazoline-5-one. The study was conducted for the qualitative and quantitative assessment of
the antimicrobial activity, as well as its influence on the adherence capacity inhibition of certain microbial strains.
Antimicrobial activity has been approached by means of instrumental techniques, such as flow cytometry. The results of this
study have demonstrated the effect of the newly synthesised compound against Gram-negative bacteria through the
permeabilization of the bacterial cell wall and against Gram-positive bacteria through the inhibition of the efflux pumps
activity.






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