VALPROIC ACID, POLYCYSTIC OVARY SYNDROME AND THE
ADOLESCENT WITH EPILEPSY
CATRINEL ILIESCU, OANA TARȚA-ARSENE*, DANA CRAIU
Paediatric Neurology, Neuroscience Department, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu
Street, District 1, Bucharest, Romania
*corresponding author: otartaarsene@yahoo.com
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Abstract:
When treating epilepsy with antiepileptic drugs (AEDs) the physician will choose the most effective drug according to the
electro-clinical syndrome and aetiology, with a minimum of side effects. Valproic acid (VPA) is in clinical use for almost 50
years and is often recommended because of its efficacy and broad spectrum of action. Recent years have brought new
information about its possible side effects, some still debated and others definitely proven. The aim of the present paper was
to discuss the association between epilepsy, chronic treatment with valproic acid in adolescence and the polycystic ovary
syndrome and to conclude with proposals on the assessment of adolescents with epilepsy who need valproic acid as their
treatment.






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