THE ELABORATION OF NOVEL ANALYTICAL METHODS FOR
CLEMASTINE AND TIMOLOL
ALEXANDRA FILARETA NEAGU*#, IOANA CLEMENTINA CONSTANTINESCU#
“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Analytical Chemistry, 6 Traian
Vuia Street, 020956, Bucharest, Romania
*corresponding author: lxndr_neagu@yahoo.com
#Authors with equal contribution
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Abstract:
Based on the reactions between clemastine/timolol and the silicotungstic acid, H4[SiW12O40], combinations by ionic
association, hardly soluble in water, having the following formula: [CL]4[SiW12O40]·2H2O and [TM]4[SiW12O40]·2H2O are
obtained. The confirmation of the structures of the new complexes and their setting conditions for processing were performed
in previous work. The obtained data were used for the development of new methods for the assay of the two studied drugs.
The established methods are accurate and reproducible.






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