NEW ACYL-OXIMINE DERIVATIVES SYNTHESIS AND THEIR
PRELIMINARY PHARMACOTOXICOLOGICAL INVESTIGATION
DANA MIHAELA CIOROIANU1, CORNEL CHIRIŢĂ2*, CARMEN LIMBAN1, ALEXANDRU VASILE MISSIR1 , ILEANA CORNELIA CHIRIŢĂ1, MIRON TEODOR CĂPROIU3, SIMONA NEGREŞ2, FLORIANA ELVIRA IONICĂ4, DIANA CAMELIA NUŢĂ1
1“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 6
Traian Vuia Street, Bucharest, Romania
2“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacology and Clinical
Pharmacy, 6 Traian Vuia Street, Bucharest, Romania
3The Organic Chemistry Centre of Romanian Academy “C. D. Neniţescu”, 202B Splaiul Independenţei, Bucharest, Romania
4University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacology, 2-4 Petru Rareș Street,
Craiova, Romania
*corresponding author: chirita.cornel@gmail.com
Download Full Article

Abstract:
The present study represents a continuation of previous research with the aim to obtain and to physicochemical characterize
some new compounds having tricyclic structure. We performed also a preliminary pharmacotoxicological investigation in
order to evaluate the compounds systemic toxicity. The structure of these substances, which are O-acyl-oximine derivatives
with 5H-dibenzo[a,d]cycloheptatrienic structure, was confirmed by elemental analysis, IR and nuclear magnetic resonance
(NMR) NMR-spectrometry.

Top