EFFECTS OF CORTICOSTEROID TREATMENT ON RESPIRATORY
MUSCLES FUNCTION IN PATIENTS WITH SEVERE OBSTRUCTIVE
LUNG DISEASE
AGRIPINA RAȘCU1,2, DANIELA ELENA POPA3*, OANA CRISTINA ARGHIR4, MARINA RUXANDRA OȚELEA1
1“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2Colentina University Hospital, Clinic of Occupational Medicine, Bucharest, Romania
3Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
4Faculty of Medicine, “Ovidius” University, Constanţa, Romania
*corresponding author: daniela.e.popa@gmail.com
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Abstract:
Glucocorticoids have remodelled the treatment of patients with obstructive lung disease (OLD) because they target
inflammation, as they represent one of their pathogenic mechanisms. The current therapeutic indications are asthma and
chronic obstructive bronchopulmonary disease (COPD), the severe form and the frequent exacerbation phenotypes, the
eosinophilic predominant inflammation subtype. Through knowledge of the possible adverse effects of long acting inhaled
corticosteroids, regarding the reduction of long-term respiratory muscle performance, could lead to the development of new
therapeutic approaches, meant to increase the survival rate and the quality of life in patients with obstructive pulmonary
disease.

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