SYNTHESIS, CHARACTERIZATION AND MICROBIOLOGICAL
ACTIVITY EVALUATION OF TWO SILVER COMPLEXES WITH
NORFLOXACIN
AURA RUSU1, GABRIEL HANCU1*, GERGŐ TÓTH2, FELICIA TOMA3, ANCA DELIA MARE3, ADRIAN MAN3, BRUNO ŞTEFAN VELESCU4, VALENTINA UIVAROȘI5
1University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, Pharmaceutical Chemistry Department, 38
Gheorghe Marinescu Street, Tîrgu Mureș, 540139, Romania
2Semmelweis University, Pharmaceutical Chemistry Department, 9 Hőgyes Endre Street, Budapest, H-1092, Hungary
3University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Medicine, Microbiology, Virology, and Parasitology
Department, 38 Gheorghe Marinescu Street, Tîrgu Mureș, 540139, Romania
4”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmacology and Clinical Pharmacy
Department, 6 Traian Vuia Street, 2 District, Bucharest, 020956, Romania
5”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, General and Inorganic Chemistry
Department, 6 Traian Vuia Street, 2 District, Bucharest, 020956, Romania
*corresponding author: gabriel.hancu@umftgm.ro
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Abstract:
Silver complexes of norfloxacin (NOR) are interesting for therapeutic purposes due to possible synergistic bactericidal and
antifungal potential provided by the metal and fluoroquinolones (FQ). In order to obtain new compounds with superior
antibacterial and antifungal properties, we synthesized two silver complexes of NOR. A multi-analytical approach was
carried out by using elemental analysis (C, H, N), conductivity measurement, differential scanning calorimetry and
spectroscopic methods (FT-IR, 1H-NMR, UV-VIS and PL). The screening of antibacterial activity and antifungal of the
complexes was performed by determination of minimal inhibitory concentration (MIC) through microtiter broth dilution
method.

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