SYNTHESIS, CHARACTERIZATION AND MICROBIOLOGICAL
ACTIVITY EVALUATION OF NOVEL HARD GELATINE CAPSULES
WITH CEFACLOR AND PIROXICAM
GEORGE TRAIAN ALEXANDRU BURCEA DRAGOMIROIU1#, DANIELA ELENA POPA1#*, BRUNO ȘTEFAN VELESCU2#, ADRIAN ANDRIEȘ3, VIOREL ORDEANU4, ALINA CRENGUȚA NICOLAE5#, CRISTINA MANUELA DRĂGOI5#, MARIA BÂRCĂ1#, OCTAV GINGHINĂ6#
1Department of Drug Control, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia
Street, 020956, Bucharest, Romania
2Departament of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and
Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
3Department of Drug Industry and Pharmaceutical Biotechnologies, Faculty of Pharmacy, “Carol Davila” University of
Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
4Scientific Military Medical Research Centre, 88 Mircea Vulcănescu Street, 010825, Bucharest, Romania
5Department of Biochemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia
Street, 020956, Bucharest, Romania
6Department of Oncological Surgery, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy,
“Sf. Ioan” Hospital, 13 Vitan-Bârzești Street, 042122, Bucharest, Romania
*corresponding author: daniela.e.popa@gmail.com
# Authors with equal contribution
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Abstract:
Cefaclor and piroxicam combination is relevant for the pharmaceutical field due to synergistic bactericidal and antiinflammatory
potential, provided by the second generation cephalosporin and first generation NSAID. In order to obtain new
products with higher pharmacological properties, we developed hard gelatine capsules with cefaclor and piroxicam, in a
fixed-dose combination. A multi-analytical approach was carried out by Fourier Transform-Infrared Spectroscopy (FT-IR)
and Thin Layer Chromatography (TLC). The screening of the antimicrobial activity of the capsules was performed by
determination of the minimal inhibitory concentration (MIC) through microtiter broth dilution method.
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