SCREENING OF THIOALKANOIC SUBSTITUTED 1,4-
NAPHTHOQUINONES AS POTENT ANTIMICROBIAL AGENTS
GABRIELA RĂU1#, FLAVIA MARIA CREŢU1#, ANCA BERBECARU-IOVAN1#*, CAMELIA ELENA STĂNCIULESCU1, ANA MARINA ANDREI1, GEORGE DAN MOGOŞANU1, MARIA BĂLĂŞOIU1,2, ILEANA MONICA BANIŢĂ1,3, CĂTĂLINA GABRIELA PISOSCHI1,2
1University of Medicine and Pharmacy, 2-4 Petru Rareş, 200349, Craiova, Dolj, Romania
2Clinical Laboratory, Emergency Clinical County Hospital, 1 Tabaci, 200642, Craiova, Dolj, Romania
3 Clinical Laboratory, Clinical Hospital of Neuropsychiatry, 99 Calea București, 200473, Craiova, Dolj, Romania
*corresponding author: ancaberbecaru@yahoo.com
#Authors with equal contribution.
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Abstract:
In the present study, there are described the synthesis and evaluation of physico-chemical properties and antimicrobial
activity of some hetero-1,4-naphthoquinones containing thiol groups substituted with alkanoic acids. The synthesis of the
new derivatives consists in a condensation between 2,3-dichloronaphthalen-1,4-dione and some thioalkanoic acids. The
structures of the pure products were characterized by spectroscopic methods. The antimicrobial activity was tested on Grampositive
and Gram-negative bacteria and the antifungal activity on Candida albicans using the disk diffusion method. The
compounds tested proved activity against Candida albicans and Gram-positive bacteria.

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