TOXICITY AND ANTI-INFLAMMATORY ACTIVITY OF ZIZIPHUS
JUJUBA MILL. LEAVES
MARILENA-VIORICA HOVANEŢ1, ROBERT VIOREL ANCUCEANU1*, MIHAELA DINU1, ELIZA OPREA2, EMMA ADRIANA BUDURA3, SIMONA NEGREŞ4, BRUNO ŞTEFAN VELESCU4, LIGIA ELENA DUŢU5, IULIANA ADRIANA ANGHEL1, IRINA ANCU6, ELENA MOROŞAN7, OANA CRISTINA ŞEREMET4
1Department of Pharmaceutical Botany, Faculty of Pharmacy, University of Medicine and Pharmacy, “Carol Davila”, 6
Traian Vuia Street, Bucharest, Romania
2Department of Organic Chemistry, Biochemistry and Catalysis, University of Bucharest, Faculty of Chemistry, 4-12 Regina
Elisabeta Boulevard, Bucharest, Romania
3Department of Pharmaceutical Technology Faculty of Pharmacy, University of Medicine and Pharmacy, “Carol Davila”, 6
Traian Vuia Street, Bucharest, Romania
4Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy, “Carol
Davila”, 6 Traian Vuia Street, Bucharest, Romania
5Department of Pharmacognosy, Phytochemistry and Phytotherapy, Faculty of Pharmacy, University of Medicine and
Pharmacy, “Carol Davila”, 6 Traian Vuia Street, Bucharest, Romania
6Research Institute for Fruit Growing, Rilomania, OP 1, CP 73, Argeș County, Romania
7Department of Clinical Laboratory and Food Safety, Faculty of Pharmacy, University of Medicine and Pharmacy, “Carol
Davila”, 6 Traian Vuia Street, Bucharest, Romania
*corresponding author: robert.ancuceanu@gmail.com
Download Full Article

Abstract:
A dried ethanolic extract, obtained from Ziziphus jujuba Mill. (Rhamnaceae) leaves, was tested in order to evaluate the
effects on plant cell division, its acute oral toxicity and anti-inflammatory properties. Two inflammation experimental models
on rats, with carrageenan and kaolin as inflammatory agents, were used. The experimental group was treated by gavage for 7
days with 5 % aqueous suspension of the extract (500 mg/kg b.w.) and the control group with 1 mL/100 g b.w. distilled
water. The reference group, in the 7th day, was treated with 0.1 % indomethacin solution (10 mg/kg b.w.). No toxic symptoms
or mortality were observed in any animals. In both inflammation models a very weak anti-inflammatory effect was detected,
a little better in the kaolin model but generally inferior to indomethacin. A statistically significant inhibitory effect on the
growth of Triticum radicles was observed at 0.5% and 1% concentrations, accompanied by microscopic signs of cytotoxicity.

Top