A REVIEW ON THE PHYSIOLOGICAL AND PHARMACOLOGICAL
INFLUENCE OF VASCULAR TONE IN CHOROIDAL AND
CONJUNCTIVAL EYE TERRITORIES
AURELIAN ZUGRAVU1#, ISABEL CRISTINA VIORICA GHIȚĂ1#*, HORIA PĂUNESCU1#, LAURENȚIU COMAN2#, OANA ANDREIA COMAN1#, ION FULGA1#
1Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, “Carol Davila” University of Medicine and
Pharmacy
2Department of Physiology, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy
*corresponding author: isabelghita@yahoo.co.uk
#All authors have an equal contribution.
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Abstract:
This review analysed the literature of the period 2006 - 2015 on the nervous and humoral control of choroidal (including the
vascularization of iris and ciliary bodies) and conjunctival vascular tone. Articles referring exclusively to pathological eye
and to retinal vasculature were excluded. Anatomically, choroidal and conjunctival vascular territories are two distinct
territories with extensive anastomosis. In both territories active substances interfering with the adrenergic, histamine and
serotonin control have been assessed. The influences in the area of the ciliary arteries/choroidal vasculature of many other
vasoactive substances were studied. For substances that have been studied in both vascular territories, there were differences
between the two territories. Differences in vascular reactivity are likely due to the variability in density of the different types
of adrenergic, histamine and serotonin receptors, respectively.

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