SYNTHESIS OF SOME NEW 2-((4-CHLOROPHENOXY)METHYL)-N-
(ARYLCARBAMOTHIOYL) BENZAMIDES AS POTENTIAL
ANTIFUNGAL AGENTS
CARMEN LIMBAN1, ALEXANDRU VASILE MISSIR1, DIANA CAMELIA NUŢĂ1*, MIRON TEODOR CĂPROIU2, MARIUS TOMA PAPACOCEA3, CORNEL CHIRIŢĂ1
1University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, Bucharest, Romania, 6 Traian Vuia
St., Bucharest, 020956, Romania
2“C. D. Neniţescu” Organic Chemistry Center of the Romanian Academy, Splaiul Independenţei 202B, Bucharest, Romania
3University of Medicine and Pharmacy „Carol Davila” Bucharest, Clinical Emergency Hospital "Sf. Pantelimon", Șoseaua
Pantelimon, 340-342, Bucharest, Romania
*corresponding author: diananuta@yahoo.com
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Abstract:
As a continuation of our previous work on the synthesis of 2-((4-chlorophenoxy)methyl)-N-(arylcarbamothioyl) benzamides and
in view of the antifungal activity characterization of these molecules, we report in this paper the obtaining of new molecules
having this chemical structure. The new benzamides were synthesized by reacting 2-(4-chlorophenoxymethyl)benzoyl
isothiocyanate with aromatic amines in dry acetone. All the chemical structures were evaluated and characterised by 1HNMR,
13C-NMR, IR spectroscopy methods and by their physical properties (melting point, solubility).






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