NON-CLINICAL TOXICITY AND PHYTOTOXICITY OF TWO
HERBAL EXTRACTS
ROBERT ANCUCEANU1, CRISTINA ELENA ZBÂRCEA2*, MARIA COJOCARU-TOMA3, TATIANA CALALB3, ADRIANA IULIANA ANGHEL1, SIMONA NEGREŞ2, MIHAELA DINU 1, MARILENA VIORICA HOVANEŢ1
1University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical
Botany and Cell Biology, 6 Traian Vuia Street, 020956, Bucharest, Romania
2University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmacology, 6
Traian Vuia Street, 020956, Bucharest, Romania
3State University of Medicine and Pharmacy “Nicolae Testemiţanu”, Faculty of Pharmacy, Department of Pharmacognosy
and Pharmaceutical Botany, 165 Stefan cel Mare și Sfint Street, Chisinau, Republic of Moldova
*corresponding author: cristinazbar@yahoo.com
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Abstract:
Two herbal extracts, one of Panax notoginseng (Burkill) F. H. Chen and the other from oat bran were tested for their toxicity
in NMRI mice, Artemia franciscana Kellogg and for their phytotoxicity on Triticum aestivum L. No lethality was recorded
and no changes in the parameters followed up were seen for any of the two extracts tested on mice. Based on the
experimental data the two extracts may be classified in the Globally Harmonized System (GHS) category 5. In the Artemia
test, the Panax notoginseng extract was virtually non-toxic (0% lethality); the oat bran extract had slight toxicity, but for all
practical purposes it may also be considered non-toxic. In the Triticum test a concentration-dependent inhibitory effect on
root elongation (p < 0.001), was seen at concentrations of 0.5% and higher (p < 0.001% versus control) in the case of Panax
notoginseng and at concentrations of 0.25% for the oat bran extract (p < 0.012); the results are in agreement with those seen
on Artemia franciscana.

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