ASSESSMENT OF IN VITRO ANTIOXIDANT AND ANTIINFLAMMATORY
ACTIVITIES OF NEW AZETIDIN-2-ONE DERIVATIVES OF FERULIC ACID
MARIA DRĂGAN1, CĂTĂLINA DANIELA STAN1*, ANDREEA IACOB2, LENUŢA PROFIRE2
Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universităţii Street, 700115, Iaşi, Romania
1Department of Drug Industry and Pharmaceutical Biotechnology
2Department of Pharmaceutical Chemistry
*corresponding author: catalinastan68@yahoo.com
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Abstract:
The in vitro antioxidant potential of new azetidin-2-one derivatives of ferulic acid was evaluated according to DPPH and
ABTS.+ radicals scavenging assays. Their anti-inflammatory effect was also evaluated using two in vitro assays: bovine serum
albumin denaturation and human red blood cell membrane stabilization. The results showed that the compound 1e (R = 4-F) was
the most active. The antioxidant effect of this compound was more intense than ferulic acid and comparable with ascorbic
acid. Also, the anti-denaturation activity of this compound was more intense than ferulic acid and comparable with diclofenac
used as positive control. Regarding the ability to protect the erythrocyte membrane it was observed that all tested compounds
showed a protection capacity comparable with diclofenac and higher than ferulic acid, at the concentration of 1100 μg/mL.

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