ANTIOXIDANT EVALUATION OF SOME COUMARIN DERIVATIVES
GABRIELA TATARINGA1, CATALINA STAN2*, CORNELIA MIRCEA3, ALEXANDRA JITAREANU1, ANA-MARIA ZBANCIOC1
1Department of Organic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy “Gr. T. Popa” Iasi, Romania
2Department of Pharmaceutical Industry, Faculty of Pharmacy, University of Medicine and Pharmacy “Gr. T. Popa” Iasi,
Romania
3Department of Pharmaceutical Biochemistry and Clinical Pharmacy, Faculty of Pharmacy, University of Medicine and
Pharmacy “Gr. T. Popa” Iasi, Romania
*corresponding author: catalinastan68@yahoo.com
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Abstract:
The present study evaluated the antioxidant potential of 28 coumarin derivatives, using three antioxidant assays: DPPH
inhibition, total reducing power and NO inhibition. Out of the tested compounds, the most active DPPH free radicals
scavengers were the coumarin hydrazide derivatives. These substances were also the only ones among the investigated
derivatives that exhibited a moderate reducing power of ferricyanide to ferrocyanide, but their activity was inferior to that
exhibited by the reference substance (ascorbic acid). Most of the tested substances were moderate NO inhibitors. The activity
of 4-methyl-7-methoxy coumarin was remarkable, exceeding the inhibitory potential of ascorbic acid.

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