GERANYLGERANYLACETONE REDUCES RADIATION-INDUCED
DEGENERATION OF SEMINIFEROUS EPITHELIUM IN MICE
BOGDAN HORAŢIU ŞERB1, ALINA ORMENIŞAN2*, VLAD PRELUCA1, MIHAELA CERNUŞCĂ-MIŢARIU1, MIHAI IOAN MIŢARIU1
1Faculty of Medicine, Lucian Blaga University of Sibiu, 2A Lucian Blaga Street, 550169, Sibiu, Romania
2Department of Oro-Maxillo-Facial Surgery, Târgu-Mureș University of Medicine and Pharmacy, Târgu-Mureș, Romania
*corresponding author: ormenisanalina@yahoo.fr
Download Full Article

Abstract:
Geranylgeranylacetone (GGA) has been shown to have cytoprotective effects against a variety of stressors via the induction
of the heat shock response. In this study, male mice received GGA by gavage in doses of 250 mg/kg body weight (kg bw)
and 1000 mg/kg bw daily for 5 days. The controls received the corresponding volume of vehicle. In the last day of treatment,
all mice received a single dose of 4 gray (Gy) total body irradiation. Blood samples were collected before irradiation and at 2
and 8 days post-irradiation. The testes were removed after euthanasia, in the 8th day post-irradiation, for histological analysis.
The results showed significant post-irradiation reduction of leukocyte and platelet counts, with no significant difference
between treatment groups and controls. The seminiferous tubule proliferation status was significantly higher in mice treated
with 1000 mg/kg bw GGA. In conclusion, GGA reduces radiation-induced degeneration of the seminiferous epithelium in mice.

Top