IR AND THERMAL CHARACTERIZATION OF NEW
SILICOTUNGSTIC ACID COMPLEXES WITH CLEMASTINE AND
TIMOLOL
ALEXANDRA FILARETA NEAGU*, IOANA CLEMENTINA CONSTANTINESCU
“Carol Davila” University of Medicine and Pharmacy Bucharest, Faculty of Pharmacy, Department of Analytical
Chemistry, 6th Traian Vuia Street, 020956, Bucharest, Romania
*corresponding author: lxndr_neagu@yahoo.com
Authors have equal contribution.
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Abstract:
Clemastine and timolol react with silicotungstic acid (H4SiW12O40) and form hardly soluble ion-associations. The structures
of the obtained complexes were confirmed by IR spectral analysis and thermogravimetric analysis coupled with differential
calorimetric analysis. The conditions for processing the complex combinations were established in order to further assay the
drugs. The chemical formula, molecular weight and solubility in water for the two complexes were determined.






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