FLUOXETINE INFLUENCE ON BODY WEIGHT, SERUM
ADIPONECTIN LEVEL AND ADIPOSE TISSUE TRIGLYCERIDES
LEVELS IN RATS
MELINDA KOLCSÁR1, ZSOLT GÁLL1,2*, ISTVÁN LÓRÁNT BÍRÓ1, LÁSZLÓ ISTVÁN BÁBA1, ANNAMARIA IMRE2, MARIA T. DOGARU1, ORSOLYA MÁRTHA3
1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy of Tîrgu
Mureș, Gh. Marinescu Street, No. 38, Târgu Mureș, Romania
2Doctoral School, University of Medicine and Pharmacy of Tîrgu Mureș, Gh. Marinescu Street, No. 38, Târgu Mureș,
Romania
3Department of Urology, Faculty of Medicine, University of Medicine and Pharmacy of Tîrgu Mureș, Gh. Marinescu street,
No.38, Târgu Mureș, Romania
*corresponding author: gall.zsolt@umftgm.ro
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Abstract:
The effects of fluoxetine on metabolic parameters are poorly understood. Adiponectin is an adipocyte hormone inversely
correlated with body fat percentage in adults. The aim of this study was to investigate the hormonal changes and metabolic
parameters of the perirenal adipose tissue of rats. Two doses (6 mg/kgbw and 12 mg/kgbw) of oral fluoxetine were
administered, and dose- and sex-dependent body weight changes were observed. In male rats a weight gain was observed in
the control group, instead in the treated groups the high doses of fluoxetine partially blocked this effect. In treated female rats
no body weight changes were observed compared to the control group. The perirenal adipose tissue triglyceride content
reduction with a simultaneous elevation of plasma adiponectin level suggests that fluoxetine had important peripheral effects.

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