EVALUATION OF THE INGESTION OF PARABENS DURING THE
USE OF DENTAL CARE PRODUCTS BY HEALTHY HUMAN
VOLUNTEERS
MIRCEA DUMITRU CROITORU, AMALIA MIKLOS*, ERZSÉBET FOGARASI, MARIA MARGARETA COMAN, IBOLYA FÜLÖP
Department of Toxicology and Biopharmacy,, Faculty of Pharmacy, University of Medicine and Pharmacy of Târgu Mureș,
38 Gheorghe Marinescu Street, 540138, Târgu Mureș, Romania
*corresponding author: amalia.miklos@yahoo.com
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Abstract:
Parabens are effective antibacterial agents for the cosmetic and food industries. Methyl and ethyl parabens have been
considered safe by regulatory authorities and an acceptable daily intake (ADI) of 10 mg/kg bw was established. Recently,
animal studies linked negative health effects with the use of heavier chained parabens. Our study focused on the safe use of
methyl and propyl parabens in dental care products, such as mouthwash and toothpaste. A HPLC-UV method was developed
for quantifying methyl and propyl parabens in dental care products and oral fluids. The results of the study, conducted on
volunteers, showed that the ingestion of methyl paraben, using mouthwash and toothpaste, was very low (only 1-2% of the
ADI). The ingested amount of propyl paraben is about the same, since these compounds are coexisting ingredients of dental
care products in similar concentrations. This could be considered toxicologically significant, if further studies would confirm
the presumption that propyl paraben can be hundred times more toxic than methyl paraben.

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