EFFECTS OF OXIDATIVE STRESS AND PHARMACOLOGYCAL
TREATMENT ON GERIATRIC SYNDROMES IN THE
HOSPITALIZED ELDERLY PATIENTS
ADINA CARMEN ILIE, IOANA DANA ALEXA*, ANCA IULIANA MOROŞANU, ADRIAN COVIC, VASILE CEPOI
"Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania
*corresponding author: ioana.b.alexa@gmail.com
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Abstract:
Oxidative stress is an important risk factor in ageing process and influences the evolution of most diseases and geriatric
syndromes in the elderly. This evolution is also affected by the pharmacokinetics and pharmacodynamics age-induced
particularities of the elderly, which lead to an increased risk for negative side effects and drug-induced toxicity than in the
adult patient. We performed a cohort, prospective study on 139 patients aged over 65 years. The aim of the study was to
determine the effects of oxidative stress and cardiovascular pharmacological treatment on geriatric syndromes in the elderly
patients. Oxidative stress was quantified by measuring the advanced glycated end products (AGE) with a skin autofluorescence
method. Geriatric syndromes were determined with comprehensive geriatric assessment. Cardiovascular drugs
studied were: beta blocker, angiotensin converting enzyme inhibitors (ACE-I) and anticoagulants. The mean age in the study
cohort was 75.35 ± 6.46 and the mean level of AGEs was 2.87 (3.27 - 2.56) AU. The levels of AGE were significantly
correlated with the presence of heart failure (p = 0.014, r = 0.280) and with the cognitive status (p < 0.05, r = 0.206). ACE-I
treatment had a positive correlation with a low depression score (p < 0.05, r = 0.235) and beta blocker treatment correlated
with a low score on abilities to live independently (p < 0.05, r = 0.233). The anticoagulant therapy was associated with the
cognitive impairment (p < 0.05, r = -0.214), patients with anticoagulant treatment had a higher score in the mini mental state
examination (MMSE) than patients without anticoagulant treatment (p < 0.05). Oxidative stress and pharmacological
treatment had correlations with geriatric syndromes.






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