ORDERED MESOPOROUS CARBON BASED SENSOR FOR
SENSITIVE DETECTION OF VITAMIN B6 IN PHARMACEUTICALS
IRINA MIRELA APETREI1, CONSTANTIN APETREI2*, OLIMPIA DUMITRIU BUZIA1
1Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati,
Romania
2Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of
Galati, Romania
*corresponding author: apetreic@ugal.ro
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Abstract:
A novel screen-printed sensor based on ordered mesoporous carbon was used for the electrochemically determination of
pyridoxine (vitamin B6) in pharmaceuticals. Various experimental parameters were studied and optimized such as the nature
and the pH of the electrolyte solution, the scanning rate and the interference of different chemical species. Optimal
electroanalytical conditions are represented by: phosphate buffer (pH 7.0) with the concentration of 0.01 mol/L and the
potential scanning rate of 0.1 V/s. In these conditions, interferences of the main compounds found in pharmaceuticals were
less than 1%. The linearity range of the sensor in order to determine the concentration of pyridoxine was from 1 to 200 μM
with a detection limit of 0.42 μM. Voltammetry was successfully applied for the quantification of vitamin B6 in
pharmaceuticals. The results obtained for the ordered mesoporous carbon-based sensor were compared to those obtained by
the standard spectrophotometric method resulting a very good correlation.

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