EVALUATION OF ANTI-INFLAMMATORY POTENTIAL OF SOME
NEW FERULLIC ACID DERIVATIVES
MARIA DRĂGAN1, CĂTĂLINA DANIELA STAN1*, ANDREEA PÂNZARIU2, LENUŢA PROFIRE2
Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universităţii Street, 700115, Iaşi,
România
1Department of Drug Industry and Pharmaceutical Biotechnology
2Department of Pharmaceutical Chemistry
*corresponding author: catalinastan68@yahoo.com
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Abstract:
The anti-inflammatory potential of new thiazolidin-4-one derivatives of ferulic acid was evaluated using in vitro assays based
on bovine serum albumin denaturation and human red blood cell membrane stabilization. The most intense anti-denaturation
effect was showed by compounds 1e (R = 2-NO2), 1f (R = 2-OH) and 1d (R = 4-NO2) for which the anti-denaturation activity
was more intense than ferulic acid and comparable with diclofenac. Considering the ability of the tested compounds to
protect the erythrocytes membrane it was observed that at 500 μg/mL, all compounds showed a protection comparable or
higher than diclofenac and ferulic acid. The results support the favourable influence of the thiazolidine-4-one moiety on the
anti-inflammatory effect of the ferulic acid derivatives.






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