DEVELOPMENT AND OPTIMIZATION OF NEW CAPSAICIN
MICROEMULSIONS FOR TOPICAL ADMINISTRATION
VICTOR COJOCARU1, LUDMILA OTILIA CINTEZĂ2*, MARIANA POPESCU3, NATALIȚA IONESCU (BORDEI)3, CONSTANTIN MIRCIOIU1
1”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia, 020956, Bucharest, Romania
2University of Bucharest, Faculty of Chemistry, 4-12 Regina Elisabeta, 030018, Bucharest, Romania
3Hofigal Export-Import S.A., Research & Development Department, 2 Intrarea Serelor, 042124, Bucharest, Romania
*corresponding author: ocinteza@yahoo.com
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Abstract:
In this paper, microemulsions were formulated using pharmaceutically acceptable components for topical administration of
capsaicin: isopropyl myristate (oil), Tween 80 (surfactant) and n-butanol/n-octanol (cosurfactants). The purpose of this study
was to develop a new method for screening the optimal composition of microemulsions based upon the investigation of the
minimum surfactant:cosurfactant ratio and the concentration of tensioactive reagents at which microemulsion formation
occurs, by determining the interfacial tension at the liquid-liquid interface between pepper tincture and oil phases.
Investigations were conducted for each surfactant-cosurfactant mixture. Also, a n-butanol/n-octanol-free system was
considered. The results obtained from the interfacial tension measurements were compared with the ones generated by the
titration method, proving the similarity between the two.

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