ANTI-INFLAMMATORY EFFECTS OF ERYNGIUM PLANUM L. AND
E. MARITIMUM L. (APIACEAE) EXTRACTS IN TURPENTINE-OIL
INDUCED ACUTE INFLAMMATION IN RATS
SIMONA CONEA (SUCIU)1*, ALINA ELENA PÂRVU2, SORANA BOLBOACĂ3
1Department of Clinical Pharmacy, “Vasile Goldiş” West University Revoluţiei Blv. 94-96, Arad, Romania
2Department of Pathophysiology, “Iuliu Haţieganu” University of Medicine and Pharmacy, 3-5 Clinicilor Street, Cluj-
Napoca, Romania
3Department of Biostatistics, “Iuliu Haţieganu” University of Medicine and Pharmacy, 6 Pasteur Street, Cluj-Napoca,
Romania
*corresponding author: suciu_simona@yahoo.com
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Abstract:
The aim of this paper was to evaluate the effects of two 1:1 fluid extracts (FE) of Eryngium planum and E. maritimum aerial
parts on acute inflammation induced by turpentine oil in rat. Results of 1:10 and 1:100 dilutions of the two extracts were
compared to those from a control group treated only with sterile saline and to a group treated with diclofenac (a nonsteroidal
anti-inflammatory drug – NSAID). Both tested extracts showed anti-inflammatory effects, because they lowered the
circulating phagocytes proliferation and activation and decreased the nitrogen oxide (NO) synthesis. On bone marrow acute
phase response, both extracts showed a very significant inhibitory action by reducing the total leukocyte number by lowering
the neutrophils percentage (acute phase phagocytes).

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