REVIEW – RECENT ENANTIOMER SEPARATION STRATEGIES OF
NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) BY
CAPILLARY ELECTROPHORESIS
ANAMARIA PODAR1, ŞOIMIŢA SUCIU2*, RADU OPREAN1
“Iuliu Haţieganu” University of Medicine and Pharmacy, 13 Emil Isac St., 400023, Cluj-Napoca, Romania
1Department of Analytical Chemistry and Instrumental Analysis; Faculty of Pharmacy
2 Department of Physiology, Faculty of Medicine
*corresponding author: mihaela.suciu@umfcluj.ro
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Abstract:
This report highlights the most recent enantiomer separation strategies applied in capillary electrophoresis (CE), using
nonsteroidal anti-inflammatory drugs (NSAIDs) 2-arylpropionic acids as model compounds. It is mainly focused on method
development and validation, along with pharmaceutical and biomedical application, where chiral selectors (CSs) are used.
There is a large number of CSs that have, over the years, been synthesized and used in electrophoretic enantioseparations. In
this review article, their advantages, their chiral recognition mechanisms and their performance are presented and discussed
in particular.






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