CURRENT STATUS AND FUTURE PERSPECTIVES IN THE
MANAGEMENT OF PREMATURE EJACULATION – A REVIEW OF
THE LITERATURE
RAZVAN MULTESCU1#, OCTAV GINGHINĂ2#*, BOGDAN GEAVLETE1#, PETRISOR GEAVLETE1#, GEORGE TRAIAN ALEXANDRU BURCEA DRAGOMIROIU3#, MARA GEORGESCU4#, VIOLETA BOJINCA5#, DRAGOS GEORGESCU1#
1Department of Urology, ”Sf. Ioan” Hospital, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy,
13 Vitan-Barzesti Street, 042122, Bucharest, Romania
2Department of Oncological Surgery, ”Sf. Ioan” Hospital, Faculty of Dental Medicine, “Carol Davila” University of
Medicine and Pharmacy, 13 Vitan-Barzesti Street, 042122, Bucharest, Romania
3Department of Drug Control, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy Bucharest, 6
Traian Vuia Street, 020956, Bucharest, Romania
4Veterinary Medicine Faculty of Bucharest, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59
Mărăşti Blvd, 011464, Bucharest, Romania
5Department of Internal Medicine and Reumatology, “Sf. Maria” Faculty of Medicine, “Carol Davila” University of
Medicine and Pharmacy, 37-39 Ion Mihalache Boulevard, 011172, Bucharest, Romania
*corresponding author: octavginghina@yahoo.com
#All authors have equal contribution.
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Abstract:
Today, new data are emerging regarding the etiology of premature ejaculation (PE), generating also new therapeutic alternatives.
Behavioral therapy and sexual counseling, application of topical agents, selective serotonin reuptake inhibitors, tricyclic
antidepressants, tramadol, phosphodiesterase type 5 inhibitors, alpha-blockers, oxytocin antagonists or interventional treatment
(circumcision, frenulotomy, selective resection of dorsal penile nerves, penile hyaluronic acid injections) are among the
therapeutic options proposed and applied for this dysfunction. Some of these alternatives are “off-label” or even still experimental.

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