ASSESSMENT OF THE IN VITRO RELEASE OF ALENDRONATE
SODIUM FROM MESOPOROUS SILICA PARTICLES
LACRAMIOARA OCHIUZ1# , MIHAELA CATALINA LUCA2#, IULIAN STOLERIU3#, MIHAELA MOSCALU2#, DANIEL TIMOFTE2,4#, GLADIOLA TANTARU1*#, ALINA STEFANACHE1#
1”Grigore T. Popa” University of Medicine and Pharmacy Iasi, Faculty of Pharmacy, 16 Universitatii Street, 700115, Iasi,
Romania
2”Grigore T. Popa” University of Medicine and Pharmacy of Iasi, Faculty of Medicine, University street, no 16, 700115,
Iasi, Romania
3“Al. I. Cuza" University, Faculty of Mathematics, 11 Bvd. Carol I, 700506, Iasi, Romania
4“Sf. Spiridon” Hospital, Surgery Department, 1 Piata Independentei, 700111, Iasi, Romania
*corresponding author: gtantaru2@yahoo.com; gladiola.tantaru@umfiasi.ro
#All authors had equal contribution to this research
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Abstract:
The objective of this study was to assess the influence of pore structure on the process of loading and releasing alendronate
(AL) from modified release particles based on mesoporous silica. Two types of systems were prepared: AL@MCM41, using
Mobile Composition of Matter no 41 (MCM 41) silica, with cylindrical pores arranged in a hexagonal structure, and
AL@MCM48, based on Mobile Composition of Matter no 48 (MCM 48) silica with cubic structure and cylindrical radial
pores diverging in three directions. After preparing the silicate matrices, AL was immobilized in the two mesoporous silica
using the adsorption technique. For each type of silica particles we performed the in vitro dissolution test with simulating
gastrointestinal fluids. Subsequently, the release profile of AL from the two types of mesoporous silica was obtained and the
AL pharmacokinetics was analysed by fitting on mathematical models. The results obtained showed that pore structure of
silicate materials have a key role in both loading capacity of silica with AL and rate of release of this drug substance.

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