UPDATES IN THE ASSESMENT OF RISK FACTORS IN
CLOSTRIDIUM DIFFICILE INFECTION IN PATIENTS WITH
INFECTIOUS DISEASES
MIHAELA CĂTĂLINA LUCA1#, FLORIN ROȘU1#, MIHNEA HURMUZACHE1#, ANDREI ȘTEFAN LUCA2#, DANIELA LECA1#, LUMINIȚA SMARANDA IANCU2#*, LĂCRĂMIOARA OCHIUZ3#
”Grigore T. Popa” University of Medicine and Pharmacy of Iasi, University Street, no 16, 700115, Iasi, Romania
1Faculty of Medicine, Department of Infectious Diseases
2Faculty of Medicine, Department of Microbiology
3Faculty of Pharmacy, Department of Pharmaceutical Technology
*corresponding author: lsiancu@mail.umfiasi.ro
#All authors had equal contribution to this research
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Abstract:
Infection with Clostridium difficile has become increasingly more frequent in recent years, being currently one of the most
common aetiology of diarrheal disease. The aim of our work was to broaden the current knowledge of the Clostridium
difficile digestive infections in patients admitted to the Infectious Diseases Hospital from Iasi City, Romania. We have
studied 166 patients with Clostridium difficile enterolactis, hospitalized between 01.01.2014 - 31.03 2015. We have found an
increasing trend in the number of cases between December 2014 and March 2015, particularly among immunocompromised
patients, 48% of cases occurred in patients with previous surgery area and 57% came from medical services. Investigation of
the used groups of antibiotics revealed that the highest risk is the use of fluoroquinolones, followed by cephalosporins.
Relapses were found in 28.67% cases, and treatment was performed with Metronidazole (66.26%), Vancomycin (5.42%) and
Vancomycin + Metronidazole (28.31%). Analysis of cases is a warning on unjustified and irrational use of antibiotics and the
danger of nosocomial infections.

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