EXPERIMENTAL INVESTIGATIONS ON THE EFFECTS OF BIDENS
TRIPARTITA EXTRACTS IN NOCICEPTIVE REACTIVITY
RAOUL VASILE LUPUŞORU1, LILIANA MITITELU-TARŢĂU2*, RAUL BOGDAN SANDU2, GRAŢIELA POPA3, MARIN ZAGNAT4, CĂTĂLINA ELENA LUPUŞORU2
“Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, code 700115, Iasi, Romania
1Faculty of Medicine, Department of Patho-Physiology
2Faculty of Medicine, Department of Pharmacology-Algesiology
3Faculty of Pharmacy, Department of Pharmaceutical Technology
4Faculty of Medical Bioengineering, Department of Bioengineering Sciences
*corresponding author: lylytartau@yahoo.com
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Abstract:
Bidens tripartita (B. tripartita), a flowering plant belonging to the Bidens genus, Compositae family, Asteroideae subfamily,
has been widely used in traditional medicine for its antiseptic, anti-inflammatory, antioxidant, astringent, diuretic, febrifuge,
narcotic and sedative effects. The present study investigated the effects of two B. tripartita extracts in somatic nociceptive
reactivity in rats. The experiment was carried out on 4 groups of 6 Wistar rats each, treated intraperitoneally for 1 month
with: group I (control): 0.5 mL/100g body weight saline solution; group II (BT-alcoholic): 200 mg/kg b.w. B. tripartita
alcoholic extract; group III (BT-aqueous): 250 mg/kg b.w. B. tripartita aqueous extract, group IV (KET): 10 mg/kg b.w.
ketoprofen. The nociceptive cutaneous testing was performed using the tail flick assay, to determine the latency time
response to tail thermal noxious stimulation. The chronic use of BT-alcoholic, but not of BT-aqueous produced a statistically
significant increase of the latency time response (p < 0.05), compared to control in the tail flick test. Its effects were less
intense than those of KET. The administration of BT-alcoholic extract showed analgesic effects in tail flick test in rats.

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