PHYTOCHEMICAL INVESTIGATIONS ON FOUR GALIUM SPECIES
(RUBIACEAE) FROM ROMANIA
ANDREI MOCAN1, GIANINA CRIȘAN1*, LAURIAN VLASE1,2, BIANCA IVĂNESCU3, ALEXANDRU SABIN BĂDĂRĂU4, ANDREEA LETIȚIA ARSENE5
1Department of Pharmaceutical Botany, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8, V. Babes Street, Cluj-
Napoca, Romania
2Department of Pharmaceutical Technology and Biopharmaceutics, “Iuliu Hatieganu” University of Medicine and
Pharmacy, 8, V. Babes Street, Cluj-Napoca, Romania
3Department of Pharmaceutical Botany, “Gr. T. Popa” University of Medicine and Pharmacy, 16, Universitatii Street, Iași,
Romania
4Department of Environmental Science, “Babeș-Bolyai” University, 30, Fântânele Street, Cluj-Napoca, Romania
5Department of Biochemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6, Traian Vuia
Street, sector 2, Bucharest, Romania
*corresponding author: gcrisan@umfcluj.ro
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Abstract:
Galium species are used as diuretics, choleretics, against diarrhea and in the treatment of some stomach complaints, gout and
epilepsy in folk medicine. Most of these species have been extensively investigated for antraquinones and iridoids but little is
known about other bioactive compounds classes. Our research aimed to investigate the chemical composition of four
Romanian species of Galium in order to bring new data related to their content in polyphenolcarboxilic acids, sterols and
methoxylated flavones. Caffeic and chlorogenic acids were identified in all samples, the richest source of chlorogenic acid
being G. odoratum (10387.8 ± 45.67 μg/g). Regarding the sterolic pattern, β-sitosterol and campesterol were detected in all
species, the richest source being G. mollugo (219.02 ± 7.24 μg/g and respectively, 15 ± 0.08 μg/g). Hispidulin was the only
identified methoxylated flavone and its highest amount was detected in G. mollugo (50.41 ± 0.03 μg/g).

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