PHYTOCOMPONENTS IDENTIFICATION IN MISTLETOE (VISCUM
ALBUM) YOUNG LEAVES AND BRANCHES, BY GC-MS AND
ANTIPROLIFERATIVE EFFECT ON HEPG2 AND MCF7 CELL LINES
DALIBORCA C. VLAD1, ROXANA POPESCU2*, VICTOR DUMITRASCU1, ADINELA CIMPORESCU3, CRISTIAN S. VLAD1, CSABA VÁGVÖLGYI4, JUDITH KRISCH5, CRISTINA DEHELEAN6, FLORIN G. HORHAT7
1Department of Biochemistry and Pharmacology, “V. Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu,
Timisoara, Romania
2Department of Cell and Molecular Biology, “V. Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu, Timisoara,
Romania
3Emergenty County Clinical Hospital, 10 Iosif Bulbuca, Timisoara, Romania
4Department of Microbiology, Faculty of Science and Informatics, University of Szeged, 52 Közép fasor, Szeged, Hungary
5Institute of Food Engineering, Faculty of Engineering, University of Szeged, 7 Mars tér, Szeged, Hungary
6Department of Toxicology, Faculty of Pharmacy, “V. Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu,
Timisoara, Romania
7Department of Microbiology, “V. Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu, Timisoara, Romania
*corresponding author: popescu.roxana@umft.ro
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Abstract:
In the present work, aqueous and alcoholic extracts of Viscum album young leaves and branches were evaluated, in order to
identify the most relevant constituents that confirm its biological activity. GC-MS was the employed technique used for
separation and identification of the extracted components. Both extracts revealed the presence of important terpenoids, fatty
acids and natural antioxidants such as vitamin E. The antiproliferative potential of the obtained extracts was also investigated on
neoplastic cell lines, HepG2 and MCF-7. The alcoholic extract was more efficient and proved a significant cytotoxic effect at
a concentration of 75 mg/mL, but inhibition of cell proliferation was also observed when the aqueous extract was used.

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