SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF NEW ACYLOXIMINES DERIVATIVES
CORNEL CHIRIȚĂ1, DANA MIHAELA CIOROIANU 2*, ILEANA CORNELIA CHIRIŢĂ2, SIMONA NEGREȘ1, BIANCA MARIAN1, CRISTINA ELENA ZBÂRCEA1
“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia St., Bucharest, 020956, Romania
1Department of Pharmacology and Clinical Pharmacy
2Department of Pharmaceutical Chemistry
*corresponding author: dana.m.cioroianu@gmail.com
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Abstract:
The present study is a follow up of previous research referring to the synthesis and characterization of new acyl-oximines
derivatives with tricyclic structure and their pharmacological activity. The structures of these new compounds were
confirmed by NMR spectra, IR spectra and elemental analysis. We continued our research by testing the biological activity of
these new compounds. The pharmacological studies of these new O-acyl-oximine derivatives with
dibenzo[a,d]cycloheptadienic structure revealed their amitriptyline-like antidepressant activity.

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