DEVELOPMENT OF A SPECTROPHOTOMETRIC METHOD FOR
DETERMINATION OF FLUOXETINE HYDROCHLORIDE IN BULK
AND PHARMACEUTICAL DOSAGE FORMS
IOANA CLEMENTINA CONSTANTINESCU*, MARINELA FLOREA, ALEXANDRA
FILARETA NEAGU
“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Analytical Chemistry,
6th Traian Vuia str., postal code 020956, Bucharest, Romania
*corresponding author: constantinescu_clementina@yahoo.com
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Abstract:
A sensitive and simple spectrophotometric method has been developed for the quantitative determination of fluoxetine
hydrochloride in bulk and pharmaceutical formulations. The yellow complex between fluoxetine hydrochloride and yellow
metanil was extracted with chloroform and its absorbance was measured at 408 nm. Beer’s low limits (1.01-10.14 μg/mL),
the molar absorptivity of 21028 L·mol-1·cm-1 and the complex composition (1:1) were determined. The stability constant,
detection and quantification limits were calculated. The proposed method has been successfully applied for the assay of drug
in pharmaceutical dosage forms.






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