SEPSIS BIOMARKERS. PAST, PRESENT AND FUTURE
CAMELIA CRISTINA DIACONU1,2*, ALICE BĂLĂCEANU1,3, ELENA MOROȘAN1,4
1“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2Internal Medicine Clinic, Clinical Emergency Hospital of Bucharest, Romania
3Internal Medicine Clinic, “Sf. Ioan” Clinical Emergency Hospital, Bucharest, Romania
4Faculty of Pharmacy, Department of Clinical Laboratory and Food Safety
*corresponding author: camiluciemi@yahoo.com
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Abstract:
Sepsis is the immunological response of systemic inflammation to bacterial, fungal or viral infection. An early diagnosis of
sepsis is essential for the successful management of this condition; it allows the prompt administration of appropriate
antibiotic regimens and avoidance of unnecessary interventions. A sepsis biomarker must be able to differentiate between
bacterial and viral infection, to indicate the severity of infection, to guide the therapy and also must be available in a timely
and cost-effective manner. Over the time, different biomarkers have been used for diagnosis of sepsis and monitoring of its
treatment. Procalcitonin and C reactive protein are probably the most widely used biochemical parameters for diagnosis and
management of patients with sepsis, together with lactate. TNF, IL-1β and IL-6 are cytokines that act as mediators of the
immunological response to infection and could be potentially useful as biomarkers of sepsis.

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