DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC
METHOD FOR DETERMINATION OF ENALAPRIL MALEATE FROM
COMMERCIAL DOSAGE FORMS
SIMONA GHERMAN*, DANIELA ZAVASTIN, ADRIAN ŞPAC, VASILE DORNEANU
“Grigore T. Popa” University of Medicine and Pharmacy of Iasi, Faculty of Pharmacy, Department of Physical Chemistry,
16 University Street, 700115, Romania
*corresponding author: simonagherman08@yahoo.com
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Abstract:
A simple, rapid and sensitive UV-spectrophotometric method was proposed for the quantitative determination of enalapril
maleate from pharmaceutical formulations. This method is based on the dissolution of enalapril in phosphate buffer pH 4,
with a maximum absorbance at 208 nm. The calibration curve was linear in the range 1 - 20 μg/mL and showed that the limit
of detection (LOD) and the limit of quantification (LOQ) were of 0.3721 μg/mL and 0.9019 μg/mL, respectively. The method
was applied for the determination of enalapril maleate from pharmaceutical dosage forms.






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