NANOPARTICLES AND ENDOTHELIUM: AN UPDATE ON THE
TOXICOLOGICAL INTERACTIONS
AYSE BASAK ENGIN1, MONICA NEAGU2, KIRILL GOLOKHVAST3, ARISTIDIS TSATSAKIS3,4*
1Gazi University, Faculty of Pharmacy, Department of Toxicology, 06330, Hipodrom, Ankara
2“Victor Babes” National Institute of Pathology, Immunology Department, 99-101 Splaiul Independentei, 050096 Bucharest,
Romania
3Far Eastern Federal University, Engineering School, Scientific Educational Centre of Nanotechnology, 690950,
Vladivostok, Russia
4University of Crete, Medical School, Department of Toxicology and Forensic Sciences, 74100, Rethymno, Greece
*corresponding author: aris@med.uoc.gr
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Abstract:
Adverse effects of environmental nanoparticles are emerged due to their escape from the macrophage surveillance and access
to microcirculation. Endothelium acts as a physiological barrier lining up the vessel walls and controls the transfer of
nanoparticles between the blood and interstitial space. Similarly, the blood–brain barrier at the level of brain microcirculation
is the major site of blood-nervous system exchange and constitutes the physical barrier. However, the loss of endothelial
function and integrity may result in the uncontrolled passage of the nanoparticles. Despite of some adverse properties, nanosized
materials continue to be used inevitably in daily life. However, their mechanism of action in the exposed organism and
their potential toxic effects are still being investigated in order to take preventive measures to save the human health. Thus,
this review focuses on the possible output of the interaction of endothelium with the nanomaterials and the significance of the
barriers during the exposure to nanoparticles.

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