ANTIPROLIFERATIVE EFFECTS OF A NOVEL MANGANESE
MITOCHONDRIAL TARGETED COMPLEX
BOGDAN ALEXANDRU STOICA1, TUDOR PETREUS2*, OANA CIOANCA3, MONICA
HANCIANU3
“Gr. T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, Iasi, Romania
1Department of Biochemistry
2Departmaent of Cell and Molecular Biology
3Department of Pharmacognosy
*corresponding author: biotudor@gmail.com
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Abstract:
Curcumin, an active compound with multiple anti-cancer properties, is able to form organo-metallic complexes which exhibit
superoxide dismutase like properties when complexed with manganese ions. The mitochondrial selectivity of a curcuminmanganese
derivative in cancer cells could be accomplished by the addition of a triphenylphosphonium (TPP) radical. In this
study, a TPP-manganese-curcumin complex was synthesized and assayed on three malignant human cell lines (melanoma,
colon adenocarcinoma and osteosarcoma). Cell viability was evaluated and IC50 was determined for each cell line, including
a control fibroblast line. For each cell line, the presence of manganese and TPP radical in the complex has improved the
cytotoxic effects. Interestingly, the presence of TPP radical has reduced the cytotoxicity only for the normal fibroblasts. The
leading mechanism for cytotoxic effects seems to be a redox one, since the presence of glutathione reduced the effects and
inhibition of intracellular glutathione synthesis increased the toxicity.

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