IN VITRO ANTIPROLIFERATIVE ACTIVITY OF FLAVONOLS:
FISETIN, QUERCETIN AND KAEMPFEROL AND THEIR
CYCLODEXTRIN COMPLEXES
CORINA DANCIU1, COSMIN CITU2, ISTVAN ZUPKO3, ROXANA GHIULAI4*, PETRU
MATUSZ5, IOANA ZINUCA PAVEL1, ALEXANDRA POPESCU6, IULIA PINZARU7,
GEORGETA SIMU6, VLAD C. DALIBORCA8
1Department of Pharmacognosy, Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy, Eftimie
Murgu Square, No. 2, 300041 Timişoara, România
2Department XII, Faculty of Medicine, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2,
300041 Timişoara, România
3Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eotvos u. 6, Szeged H-6720, Hungary
4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy,
Eftimie Murgu Square, No. 2, 300041 Timişoara, România
5Department of Anatomy and Embryology, Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy,
Eftimie Murgu Square, No. 2, 300041 Timişoara, România
6Department of Physical Chemistry, Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy, Eftimie
Murgu Square, No. 2, 300041 Timişoara, România
7Department of Toxicology, Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu
Square, No. 2, 300041 Timişoara, România
8Department of Biochemistry and Pharmacology, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu
Square, No. 2, 300041 Timişoara, România
*corresponding author: roxanaghiulai@yahoo.com
DownloadDownload Full Article

Abstract:
The aim of this study was to evaluate the in vitro antiproliferative capacity of the flavonols: fisetin, quercetin and kaempferol
alone and incorporated in β-cyclodextrins, on A2780 (human ovarian carcinoma cells), MDA-MB-231 (human breast cancer
cells) and SiHa (human cervix cancer cells). On the selected cell lines, among the tested compounds, fisetin was the most
active in terms of antiproliferative activity. The most sensitive cell line to the tested flavonols was found to be the human
ovarian carcinoma A2780 cell line. The inclusion complexes between the selected flavonols with ramified β-cyclodextrins
determined different effects, depending on the cell line and on the tested compound.






Top