STUDY ON ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY AND
PHENOLIC CONTENT OF ETHANOLIC EXTRACT OF HUMULUS
LUPULUS
ANDREEA LETIȚIA ARSENE1, STELIANA RODINO2*, ALINA BUTU2, PETRUTA
PETRACHE3, OVIDIU IORDACHE4, MARIAN BUTU2
1Department of Biochemistry, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
2National Institute of Research and Development for Biological Sciences, Bucharest, Romania
3EUROCIMPIA SRL, Arges, Romania
4National Institute of Research and Development for Textile and Leather, Bucharest, Romania
*corresponding author: steliana.rodino@yahoo.com
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Abstract:
The vegetal material is an inexhaustible source of biologically active compounds. It was already demonstrated that secondary
metabolites of plant origin have practical application in the industry of food and beverage, drugs, and flavours. Furthermore,
considering the acquired resistance of bacterial pathogens to existing antibiotics, research on new molecules of plant products
is nowadays of great interest. Taking all these into consideration, we conducted a study on the inhibitory activity of Humulus
lupulus L. (hops) extract against several gram negative and gram positive bacteria, (Bacillus subtilis, Enterococcus faecalis,
Bacillus cereus, Staphylococcus aureus, Enterobacter cloacae, Pseudomonas fluorescens and Escherichia coli). The
antimicrobial activity was performed by diffusion methods. The hops extract was also studied for its radical scavenging
activity and total phenol content and total flavonoid content. The results obtained indicated that the hops extract could be
used as raw material in the design of a plant based antimicrobial product.

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