IN VITRO IN VIVO CORRELATION BASIS AND APPLICATION TO
SLOW RELEASE INJECTABLE FORMULATION, A REVIEW
JEAN-MICHEL CARDOT1*, IVANA TOMIC1,2
1Université d’Auvergne, Faculté de Pharmacie, Laboratoire de Biopharmacie EA 4678, 28 Place H. Dunant 63001
Clermont-Ferrand, France
2Novartis AG PHAD, Analytical Development Physic Garden 3, 2.01CH-4002, Basel, Switzerland
*corresponding author: j-michel.cardot@udamail.fr
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Abstract:
The aim of the present paper is to present the basic knowledge about in vitro in vivo correlations (IVIVC). The various
definitions are given as well as the requirements to establish IVIVC. The basic concepts and IVIVC use and limitations are
described. Application to slow release injectable formulations is presented at the end of the paper as a particular example of
IVIVC.






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